Publications by authors named "S Iannazzo"
Introduction: Efgartigimod and ravulizumab, both approved for treating acetylcholine receptor auto-antibody-positive (AChR-Ab+) generalized myasthenia gravis (gMG), have not been directly compared. This paper assessed comparative effects of efgartigimod vs. ravulizumab for treating adults with AChR-Ab+ gMG using indirect treatment comparison methods.
View Article and Find Full Text PDFIntroduction: For patients with generalized myasthenia gravis (gMG), the association between symptom severity, often measured with the Myasthenia Gravis Activities of Daily Living (MG-ADL) instrument, and utility values is unknown.
Methods: Data was analyzed from the phase 3 ADAPT trial, which included adult patients with gMG randomly assigned to treatment with efgartigimod + conventional therapy (EFG + CT) or placebo + CT (PBO + CT). MG-ADL total symptom scores and the EQ-5D-5L, a measure of health-related quality of life (HRQoL), were collected biweekly up to 26 weeks.
The most serious complication in the treatment of hemophilia A (HA) is the development of factor (F)VIII inhibitors or antidrug antibodies (ADA) occurring in 25-35% of patients with severe HA. The immunological mechanisms underlying the development of ADA against FVIII products have not been completely understood yet. Immunological danger signals associated with events such as infection or surgery have been suggested to play a critical role.
View Article and Find Full Text PDFEmergency Medical Services Calls Analysis for Trend Prediction during Epidemic Outbreaks: Interrupted Time Series Analysis on 2020-2021 COVID-19 Epidemic in Lazio, Italy.
Int J Environ Res Public Health
May 2022
Article Synopsis
- During the COVID-19 outbreak in Lazio, there was a significant increase in emergency medical service (EMS) calls, prompting a study to explore the link between these calls and the progression of the epidemic.
- The researchers analyzed EMS call data and COVID-19 case trends to determine correlations, using regression models to predict changes in the epidemic based on the pattern of EMS calls over time.
- The study found that variations in EMS calls closely correlate with the rate of ICU admissions, particularly with a notable predictive value at 7 days, suggesting that tracking EMS calls can help public health predict upcoming trends in COVID-19 cases.
This research aimed to compare the relative efficacy of avapritinib versus midostaurin for patients with advanced systemic mastocytosis. A systematic literature review was performed to identify relevant evidence. Unanchored matching-adjusted indirect comparisons were conducted for overall survival (OS), overall response rate (ORR) and complete remission (CR).
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