Publications by authors named "S Ia FRENKEL'"
Purpose: Trilateral retinoblastoma (TRB), intracranial neoplasm in heritable retinoblastoma patients, is a very rare fatal disease. Many ocular oncology centers conduct routine screening of retinoblastoma patients by brain imaging. Nevertheless, there is a debate regarding its ability to prolong TRB patients' survival and the number-needed-to-treat.
View Article and Find Full Text PDFPurpose: To compare the clinical outcomes of children with unilateral retinoblastoma (Rb) and high-risk histopathology features (HRHF) following upfront enucleation with/without adjuvant chemotherapy, and investigate cases locally considered non-HRHF but converted to a standardized HRHF definition.
Design: Retrospective multinational clinical cohort study.
Methods: Children with Rb who presented to 21 centers from 12 countries between 2011-2020, and underwent primary enucleation were recruited.
Article Synopsis
- Sleep disturbances are common in advanced cancer patients, affecting 30-78% of them, yet there are few rigorous studies on treatment options.
- This study tested the effectiveness and safety of temazepam and prolonged-release melatonin against a placebo for treating insomnia in advanced cancer patients, with a total of 21 participants.
- Both temazepam and melatonin resulted in a significant reduction in insomnia severity compared to placebo, but did not improve overall quality of life; further research with more participants is needed to confirm these results.
Article Synopsis
- The study aimed to analyze high-risk histopathological features in eyes with retinoblastoma (RB) after enucleation and compare patient outcomes globally.
- A total of 1,426 RB cases were reviewed, revealing significant differences in histopathological features across continents, with Asia showing the highest rates of massive choroidal invasion and optic nerve invasion.
- The findings indicated that patients from South America and Asia faced greater risks of tumor recurrence, systemic metastasis, and mortality compared to those from Australia, Europe, and North America.
Study Objectives: The Multiple Sleep Latency Test (MSLT) is a key diagnostic component in the diagnosis of central disorders of hypersomnolence. Due to time constraints, it is common practice to wake patients at a standard time from overnight polysomnography (PSG) prior to the MSLT. This has the potential to influence MSLT results due to sleep deprivation.
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