Publications by authors named "S I Stupp"
Article Synopsis
- Researchers are working on creating synthetic soft materials that mimic living organisms' behaviors, specifically those that can sense and adapt to their environments.
- This study focuses on a hybrid hydrogel made from peptide amphiphile nanofibers and photoresponsive materials that can swim using aligned ferromagnetic nanowires and respond to light.
- The findings showcase the potential of using hybrid polymers that combine supramolecular and covalent structures to develop intelligent systems that can autonomously react to their surroundings.
Article Synopsis
- Ferroelectric materials can switch their polarization with electric fields and are useful for applications in information storage, energy management, low-power electronics, and biomedical devices.
- Soft ferroelectrics, particularly those based on poly(vinylidene fluoride) (PVDF), often have high coercive fields and complex structures, which limit their effectiveness.
- A new type of ferroelectric material, created from water-soluble molecules and a peptide, shows improved characteristics like a much lower coercive field and a higher Curie temperature, making it a promising candidate for sustainable, advanced ferroelectric applications.
Although autologous chondrocyte transplantation can be effective in articular cartilage repair, negative side effects limit the utility of the treatment, such as long recovery times, poor engraftment or chondrogenic dedifferentiation, and cell leakage. Peptide-based supramolecular polymers have emerged as promising bioactive systems to promote tissue regeneration through cell signaling and dynamic behavior. We report here on the development of a series of glycopeptide amphiphile supramolecular nanofibers with chondrogenic bioactivity.
View Article and Find Full Text PDFPorous titanium addresses the longstanding orthopedic challenges of aseptic loosening and stress shielding. This work expands on the evolution of porous Ti with the manufacturing of hierarchically porous, low stiffness, ductile Ti scaffolds via direct-ink write (DIW) extrusion and sintering of inks containing Ti and NaCl particles. Scaffold macrochannels were filled with a subtherapeutic dose of recombinant bone morphogenetic protein-2 (rhBMP-2) alone or co-delivered within a bioactive supramolecular polymer slurry (SPS) composed of peptide amphiphile nanofibrils and collagen, creating four treatment conditions (Ti struts: microporous vs.
View Article and Find Full Text PDFRegeneration of hyaline cartilage in human-sized joints remains a clinical challenge, and it is a critical unmet need that would contribute to longer healthspans. Injectable scaffolds for cartilage repair that integrate both bioactivity and sufficiently robust physical properties to withstand joint stresses offer a promising strategy. We report here on a hybrid biomaterial that combines a bioactive peptide amphiphile supramolecular polymer that specifically binds the chondrogenic cytokine transforming growth factor β-1 (TGFβ-1) and crosslinked hyaluronic acid microgels that drive formation of filament bundles, a hierarchical motif common in natural musculoskeletal tissues.
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