Publications by authors named "S I Roĭtman"
Article Synopsis
- Tetrapyrroles like heme, chlorophyll, and vitamin B are crucial for metabolic processes and are derived from 5-aminolevulinic acid (5-ALA), which can be synthesized via a single enzyme or a two-enzyme pathway.
- Researchers analyzed metagenomic datasets to find alaS homologs (valaS) in marine and freshwater phages, indicating these viruses may have genes for tetrapyrrole biosynthesis.
- The study demonstrates that a freshwater phage valaS can functionally complement a 5-ALA deficient E. coli strain, confirming its role as an auxiliary metabolic gene and highlighting the significance of tetrapyrrole metabolism in phage biology.
Background: Mansonellosis is an undermapped insect-transmitted disease caused by filarial nematodes that are estimated to infect hundreds of millions of people. Despite their prevalence, there are many outstanding questions regarding the general biology and health impacts of the responsible parasites. Historical reports suggest that the Colombian Amazon is endemic for mansonellosis and may serve as an ideal location to pursue these questions.
View Article and Find Full Text PDFMansonellosis is an undermapped insect-transmitted disease caused by filarial nematodes that are estimated to infect hundreds of millions of people globally. Despite their prevalence, there are many outstanding questions regarding the general biology and health impacts of the responsible parasites. Historical reports suggest that the Colombian Amazon is endemic for mansonellosis and may serve as an ideal location to pursue these questions in the backdrop of other endemic and emerging pathogens.
View Article and Find Full Text PDFPhosphatases of regenerating liver (PRL-1, PRL-2, PRL-3; also known as PTP4A1, PTP4A2, PTP4A3, respectively) control intracellular magnesium levels by interacting with the CNNM magnesium transport regulators. Still, the exact mechanism governing magnesium transport by this protein complex is not well understood. Herein, we have developed a genetically encoded intracellular magnesium-specific reporter and demonstrate that the CNNM family inhibits the function of the TRPM7 magnesium channel.
View Article and Find Full Text PDFVirophages are small double stranded DNA (dsDNA) viruses that can only replicate in a host by co-infecting with another virus. Marine algae are commonly associated with virophage-like elements such as Polinton-like viruses (PLVs) that remain largely uncharacterized. Here we isolated a PLV that co-infects the alga Phaeocystis globosa with the Phaeocystis globosa virus-14T (PgV-14T), a close relative of the "Phaeocystis globosa virus-virophage" genomic sequence.
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