Publications by authors named "S I Posokhov"

Objective: To identify valid parameters of heart rate variability (HRV) and musculoskeletal movements based on ballistocardiography data, which allow predicting the sleep efficiency (SE) index in healthy individuals and patients with insomnia.

Material And Methods: Ten healthy individuals and 14 patients with chronic insomnia were examined using polysomnography and ballistocardiography. A regression analysis of the data was carried out, as well as a reliability check of the resulting mathematical model.

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Article Synopsis
  • Sleep quality and duration decreased during prolonged Dry Immersion (DI), a ground-based model for studying microgravity, with significant changes in sleep architecture observed by the third day.
  • On DI3, participants experienced severe back pain, increased sleep latency, and disruption in REM sleep, which improved by DI10 when pain subsided.
  • By DI19 and the recovery phase, REM sleep duration increased again and showed varying correlations with blood pressure, suggesting a link between sleep changes and cardiovascular regulation during prolonged exposure to altered conditions.
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Changes in the frequency characteristics of EEG alpha rhythm in during falling asleep were studied in three healthy individuals under conditions of long-term isolation (MARS-500 project). Falling asleep was preceded by enhanced alpha rhythm frequency. An inverse correlation between the duration of falling asleep and prevailing alpha rhythm frequency during active and relaxed wakefulness was revealed in the left hemisphere.

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22 patients with panic disorder without agoraphobia, 19 patients with paroxysmal atrial fibrillation and 43 healthy control subjects with use clinic technique, psychometric, neuropsychological, neurophysiological methods (quantitative EEG and auditory event-related potentials P300) were examined. Patients with panic disorder was differed from patients with paroxysmal atrial fibrillation by higher level of anxiety and greater degree cognitive functions disturbances. In comparison with healthy control subjects at panic disorders increased of P300 peak amplitude and the spectral power of EEG beta and theta bands in the right hemisphere was observed, at paroxysmal atrial fibrillation--decreased of P300 peak amplitude and the spectral power of EEG beta band in the both hemispheres.

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We studied 34 patients with panic disorder, 32 patients with generalized anxiety disorder and 29 healthy controls using clinical-neurological, psychometric, neuropsychological and neurophysiological (auditory event-related potentials) methods. Patients were characterized by pronounced autonomic dysfunctions, a higher level of anxiety and depression as well as cognitive function disturbances in the form of impairment of short-term memory and directed attention in comparison with healthy controls. Patients with generalized anxiety disorder differed from patients with panic disorder by the higher level of anxiety, greater degree of depression and more expressed disturbances of short-term memory and directed attention.

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