Effects of antibiotic physicochemical properties on their release kinetics from biodegradable polymer microparticles.

Purpose: This study investigated the effects of the physicochemical properties of antibiotics on the morphology, loading efficiency, size, release kinetics, and antibiotic efficacy of loaded poly(DL-lactic-co-glycolic acid) (PLGA) microparticles (MPs) at different loading percentages.

Methods: Cefazolin, ciprofloxacin, clindamycin, colistin, doxycycline, and vancomycin were loaded at 10 and 20 wt% into PLGA MPs using a water-in-oil-in water double emulsion fabrication protocol. Microparticle morphology, size, loading efficiency, release kinetics, and antibiotic efficacy were assessed.

[Features of cardiologic diseases prevalence among individuals engaged into geology].

The authors studied influence of work and living conditions on geologists' health state. A cohort under study demonstrated paradoxical epidemiologic situation with high mortality risk of arterial hypertension, whereas prevalence of this disease among specialists working on expeditionary shifted mode is nearly equal to that among general population. Unfavorable situation concerning cardiovascular diseases could be caused by high prevalence of cardiovascular risks and some occupational hazards.

[Cardiological pathology in geological professionals].

The staff of the Medical Center "MEDGEO" have surveyed the working conditions and everyday life determined by the specific features of their watch-and-expeditionary work for their impact on the health status of geological workers. Since 1975, more than 13,000 specialists of the industry and members of their families have been examined in different climatic and geographical regions of the country, including 5,689 persons directly in their working places. More than 3,000 specialists have been studied in the clinical setting by using comprehensive diagnostic techniques.