Publications by authors named "S I Ochkur"
Pollen is a key source of aeroallergens responsible for allergic rhinitis, conjunctivitis, and asthma. The goal of this scoping review was to summarize current available literature on the factors that affect pollen counts, allergenicity, and thresholds that induce symptoms in individuals who were sensitized. Several databases showed no published articles with a similar scope as of January 2022.
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- - A study was conducted to test dexpramipexole, a new oral drug aimed at reducing eosinophils in patients with eosinophilic asthma, to see if it is safe and effective.
- - In a trial involving 103 participants, those taking dexpramipexole (especially the 150 mg and 75 mg doses) showed significant reductions in eosinophil levels compared to the placebo group and maintained a good safety profile.
- - The results indicate that dexpramipexole effectively lowers eosinophils, but more extensive studies are needed to evaluate its overall impact on asthma outcomes.
Objective: To evaluate eosinophil peroxidase (EPX) as a biomarker for tissue levels of eosinophilia, cytokines, and chemokines within chronic rhinosinusitis (CRS).
Methods: Twenty-eight subjects undergoing sinonasal surgery were prospectively enrolled. Ethmoid tissue was analyzed with an in-house EPX immunoassay and a 48-plex cytokine-chemokine array.
Background: Group 2 innate lymphoid cells (ILC2s) are critical mediators of type 2 respiratory inflammation, releasing IL-5 and IL-13 and promoting the pulmonary eosinophilia associated with allergen provocation. Although ILC2s have been shown to promote eosinophil activities, the role of eosinophils in group 2 innate lymphoid cell (ILC2) responses is less well defined.
Objective: We sought to investigate the role of eosinophils in activation of ILC2s in models of allergic asthma and in vitro.