[The HLA antigen system in patients with pneumoconiosis].

The antigenic HLA spectra, loci A, B and C, were explored in 102 patients suffering from pneumoconiosis of workers exposed to dust in machine building. Significant frequency differences were discovered in some antigens and their complexes (AI; A I B 8; Bw35 Cw4) between the patients and control group subjects (112 healthy persons). The patients with uncomplicated pneumoconiosis and coniotuberculosis manifested appreciable differences in the antigenic HLA spectra.

[HLA antigens and prognosis of the development of pneumoconiosis].

Basing on the studies of the HLA spectra of the A, B and C locuses in 102 pneumoconiosis patients working at a machine-building plant, and 112 healthy persons, the author proposes a technique for calculating the integral coefficient of pneumoconiosis risks. The integral coefficient 0-2 provides a criterion for distinguishing between healthy and pneumoconiosis cases. The coefficient can be used in screening of workers engaged in dust-exposed profession in machine-building industries, who may require preventive medical examination performed on a regular basis.