Publications by authors named "S I Laporte"
Objective: To describe the priors and decision thresholds in phase 2 and 3 RCTs evaluating drug efficacy using Bayesian methods.
Study Design And Setting: A systematic review of phase 2 and 3 RCTs evaluating drug efficacy through Bayesian inference was conducted across the MEDLINE, EMBASE and Cochrane databases, with no date restrictions until September 2022. The type of prior used for the analysis of the primary endpoint and its characteristics (type and parameters of the distribution, justification, sensitivity analysis), the use of a posterior probability decision threshold defined a priori, and its value, were extracted.
Article Synopsis
- The study investigates the interaction between Ang-(1-7) and the ET-1 system in the context of pulmonary hypertension, suggesting that Ang-(1-7) opposes harmful effects of ET-1.
- Research methods include various models (in vivo in mice, ex vivo in isolated arteries, and in vitro in human cells) that demonstrate Ang-(1-7) treatment reduces pulmonary vascular damage and promotes vasodilation.
- Findings reveal a complex signaling network involving MasR and ETR that protects against vascular injury, highlighting the potential for enhancing this pathway to improve vascular health.
Enhanced Gαq Signaling in -deficient Cells Is Required for Their Neoplastic Behavior.
Am J Respir Cell Mol Biol
November 2024
Article Synopsis
- Inherited or sporadic loss of a specific gene can lead to pulmonary lymphangioleiomyomatosis (LAM), a rare lung disease caused by tumor nodules that display characteristics of neural crest and smooth muscle cells.
- The abnormal growth of these "LAM cells" is linked to increased activity of the mTORC1 protein, which is typically regulated by the TSC1-TSC2 protein complex; while rapamycin slows LAM progression, it does not eliminate the disease, suggesting other processes are involved.
- Recent studies have identified G-protein coupled urotensin-II receptor (UT) signaling as a key player in LAM's cancer-related signaling, revealing that enhanced signaling through UT promotes harmful cell behaviors in
Background: Any surgical procedure carries a risk for venous thromboembolism (VTE), albeit variable. Improvements in medical and surgical practices and the shortening of care pathways due to the development of day surgery and enhanced recovery after surgery, have reduced the perioperative risk for VTE.
Objective: A collaborative working group of experts in perioperative haemostasis updated in 2024 the recommendations for the Prevention of perioperative venous thromboembolism published in 2011.
Cancer-associated venous thromboembolism (CAT) is common in patients with cancer and associated with significant morbidity and mortality. The incidence of CAT continues to rise, complicating patient care and burdening healthcare systems. Patients with cancer experiencing VTE face poorer prognoses, making prevention and effective management imperative.
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