[Prevention and treatment of postoperative pain syndrome in extensive thoracoabdominal oncological surgery].

A procedure has been developed and tested to prevent and treat postoperative pain syndrome during extensive thoracoabdominal surgery for esophageal cancer. The procedure is based on the preventive (12 hours before anesthesia and surgery) application of Durogesic (fentanyl transdermal therapeutic system (TTS)) at an opioid release rate of 50 microg/h for 72 hours. By the end of surgery and anesthesia when intravenous injection of fentanyl is stopped, analgesia continues to be maintdined due to its therapeutic dose coming from TTS.

[The influence of cytaphate on the status of oxidative metabolism in rats with diabetic nephropathy].

The antioxidant effect of cytaphate (0,0-dimethyl-N-cytisinyl phosphate) has been studied in outbred white rats with alloxan-induced insulin-dependent diabetes mellitus. The content of malonic dialdehyde, diene conjugates, ketodienes, middle-weight molecules, primary and secondary products of lipid peroxidation (LPO), and Schiff bases and the activity of catalase, glutathione peroxidase, and adenosine deaminase in erytrocytes have been evaluated. The state of oxidative protein modification, the content of malonic dialdehyde and diene conjugates, and the superoxide-anion production in the blood plasma have been determined.

[Effects of constant magnetic field on the growth and metastasizing of Lewis carcinoma in mice].

In mice with the metastasizing Lewis carcinoma the constant magnetic field (CMF) was studied for its effect on growth and metastatic process depending on the immobilization of animals. The results obtained show a decrease in the rate of the primary tumour growth and in the intensity of the metastatic process under the influence of CMF by incomplete immobilization. Complete immobilization eliminates the antimetastatic effects of the CMF.