Publications by authors named "S I Krivenko"
Invasive fungal infections are a major threat to a large cohort of immunocompromised patients, including patients with chemotherapy-associated neutropenia. Early differential diagnosis with bacterial infections is often complicated, which leads to a delay in empirical antifungal therapy and increases risk for adverse outcome. Accessibility and performance of specific fungal antigen and PCR-tests are still limited, while sepsis biomarkers are more broadly used in most settings currently.
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- The study examined the use of oral colistin to eradicate multidrug-resistant (MDR) and extensively drug-resistant (XDR) gram-negative bacteria from the intestines of patients with blood cancers undergoing chemotherapy.
- Patients receiving colistin showed a higher short-term success rate in decolonization compared to those not treated, and fewer developed bloodstream infections (BSI) within 30 days post-treatment.
- However, the long-term benefits were less clear, as the colonization rates and BSI risk were similar to the control group after 90 days, indicating that while colistin may help in the short run, it does not provide lasting protection.
The role of MSCs in infection prevention and treatment is still discussed in transplant and hematological patients. The spectrum and risk factors for infections after MSCs transplantation in patients with acute GVHD have not been studied before. To determine the risk factors and spectrum of infectious complications in patients received mesenchymal stem cell transplantation as a treatment for acute GVHD.
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