[OPTIMIZATION OF PRECLINICAL TRAINING OF ANAESTHESIOLOGISTS BASED ON THE FORMATION OF PATHOGENIC SIMULATION LEARNING ENVIRONMENTS].

Simulation training has become an important component of the postgraduate training of anaesthesiologists for several reasons: organizational difficulties in obtaining primary professional skills in a clinical setting, the opportunity to study in a hospital existing pathology only and not planned in accordance with the curriculum. This increases the risk of medical malpractice of young specialist and study may be accompanied by complications and increasing the cost of treatment. In our work, we have studied the factors of continuity of preclinical and clinical stages of anaesthesiologists training in inhalation anaesthesia based on the use of modern simulation technologies.

[Role and place of albumin dialysis in the treatment of patients with hepatic insufficiency].

The term "hepatic insufficiency" (HI) unites various hepatic dysfunctions that may be further completely compensated and that may progress until coma develops. Comprehensive examination and treatment were performed in 96 patients (64 males and 32 females) with HI. Irrespective of an etiological factor and a HI form, all the patients were divided into three groups.

[The oxidant-antioxidant system and cognitive functions in patients undergoing elective abdominal operations under various general anesthesia modes].

The impact of various general anesthesia modes on the oxidant-antioxidant system (OAS) and cognitive function in the perioperative period was studied in 88 patients (4 groups, each comprising 22 patients according to the mode of general anesthesia who had undergone elective surgery for chronic calculous cholecystitis (out of an exacerbation) and inguinal, umbilical, and postoperative hernias. Oxidative protein and lipid damages with the lower activity of antioxidant defense enzymes were found in the surgical patients exposed to various modes of general anesthesia. The findings suggest that the pattern of changes in OAS parameters depends on the method of anesthetic maintenance.

[State of prostanoid-regulating function of the lungs in patients subjected to thoracic surgery].

Lung capacity to regulate the level of plasma prostanoids at the expense of their destruction or extra synthesis is one of their numerous non-gas-exchange functions. Prostaglandins A, E, and F, prostacyclin, and thromboxane were measured in the arterial and venous blood of 23 patients before and after surgery. The level of prostanoids was sharply increased in surgical patients.

[State of the kinin-regulating function of the lungs in the perioperative period in patients undergoing thoracic surgery].

Kallikrein-kinin system (prekallikrein and kallikrein) has been studied in arterial and mixed venous blood of 22 patients operated on the lungs and mediastinum for suppurative processes and tumors and in 15 patients operated on for ischemic heart disease (aortocoronary bypass surgery). The study was conducted before surgery, immediately after the operation was over, and 8 to 10 hours after surgery. It has been observed that the lungs do not play an essential part in the regulation of background plasma kallikrein activity.