Publications by authors named "S I Hii"
Purpose: Azole resistance in poses a significant challenge in the management of invasive aspergillosis. This study aimed to investigate the antifungal susceptibility and mutation profiles of isolates in Malaysia.
Patients And Methods: Sixty clinical isolates were collected and subjected to antifungal susceptibility testing (AFST) and molecular analysis.
Article Synopsis
- qPCR is emerging as a significant method for diagnosing soil-transmitted helminths (STHs), especially for differentiating species like Strongyloides stercoralis and hookworms, but its effectiveness can be impacted by how samples are preserved and DNA is extracted.
- In a study involving 3,063 schoolchildren in Angola, qPCR's results were compared to the traditional Kato-Katz technique, showing comparable prevalence for some infections while qPCR identified a higher prevalence of hookworms.
- The agreement between the methods varied, being very good for Ascaris lumbricoides, moderate for Trichuris trichiura, and fair for hookworm, indicating a need for further research on preservation and extraction techniques to
Background: Ivermectin mass drug administration (MDA) is effective for controlling onchocerciasis and scabies, with evidence supporting its role in some species of soil-transmitted helminth (STH) infections. In the context of RISE, a cluster-randomised trial for scabies, this study evaluated the effectiveness of ivermectin MDA in reducing STH burden in the Western Province of Solomon Islands.
Methods: Twenty villages were randomised 1:1 to receive ivermectin MDA as one dose (IVM-1) or two doses (IVM-2) for scabies.
Assessing the colony morphotypes and antibiotic susceptibility profile of Malaysian clinical Burkholderia pseudomallei to support the use of EUCAST disk diffusion breakpoints to determine antibiotic resistance.
Eur J Clin Microbiol Infect Dis
February 2024
Burkholderia pseudomallei is intrinsically resistant to many antibiotics. This study aimed to assess bacterial colony morphotypes and the validity of using disk diffusion method (DD) to determine antibiotic resistance in Malaysian clinical B. pseudomallei isolates for ceftazidime (CAZ), meropenem (MEM), amoxicillin-clavulanate (AMC) and doxycycline (DOX).
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- The CoDe-STH trial in Dak Lak, Vietnam, tested whether community-wide mass drug administration (MDA) is more effective than school-based preventive chemotherapy (PC) alone in reducing soil-transmitted helminth (STH) infections in schoolchildren.
- The study involved 64 primary schools, randomly assigned to either the school arm (targeted PC) or community arm (MDA), with children receiving a single dose of albendazole for deworming.
- While both approaches reduced hookworm prevalence similarly, the community arm showed a significantly greater reduction in infection intensity, demonstrating the advantage of community-wide treatment in managing STH infections.