Publications by authors named "S I Guido"
Tumours often display invasive behaviours that induce fingering, branching and fragmentation processes. The phenomenon, known as diffusional instability, is driven by differential cell proliferation, migration, and death due to the presence of metabolite and catabolite concentration gradients. An understanding of the intricate dynamics of this spatially heterogeneous process plays a key role in the investigation of tumour growth and invasion.
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- Ovine pulmonary adenocarcinoma (OPA) is a serious lung disease in sheep that affects their health and costs farmers money.* -
- Scientists created a model to study OPA by giving sheep a virus called JSRV, and they found that different amounts of the virus led to various types of tumors.* -
- They used imaging techniques like CT scans and ultrasounds to monitor the tumors, discovering that these tools can effectively track the disease's progress, which helps improve research.*
This study introduces a novel mechanobiology assay, named "i-Rheo-optical assay", that integrates rheology with optical microscopy for analysing the viscoelastic properties of multicellular spheroids. These spheroids serve as three-dimensional models resembling tissue structures. The innovative technique enables real-time observation and quantification of morphological responses to applied stress using a cost-effective microscope coverslip for constant compression force application.
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