Publications by authors named "S I Grivennikov"
Immunoglobulin A (IgA) is the most abundant antibody isotype produced across mammals and plays a specialized role in mucosal homeostasis . Constantly secreted into the lumen of the intestine, IgA binds commensal microbiota to regulate their colonization and function with unclear implications for health. IgA deficiency is common in humans but is difficult to study due to its complex aetiology and comorbidities .
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- Colorectal cancer (CRC) is a common and serious cancer in the U.S., affecting about 135,000 people each year and causing around 50,000 deaths.
- Some people with a genetic disease called autosomal dominant polycystic kidney disease (ADPKD), which affects kidneys, might have a lower chance of getting CRC.
- Studies using mice show that when the gene PKD1 is missing, it can reduce the risk and growth of CRC, possibly helping us understand how genetics influence this type of cancer.
Background & Aims: Aberrant DNA methylation is frequent in colorectal cancer (CRC), but underlying mechanisms and pathologic consequences are poorly understood.
Methods: We disrupted active DNA demethylation genes Tet1 and/or Tdg from Apc mice and characterized the methylome and transcriptome of colonic adenomas. Data were compared to human colonic adenocarcinomas (COAD) in The Cancer Genome Atlas.
Background & Aims: Advanced colorectal carcinoma (CRC) is characterized by a high frequency of primary immune evasion and refractoriness to immunotherapy. Given the importance of interferon (IFN)-γ in CRC immunosurveillance, we investigated whether and how acquired IFN-γ resistance in tumor cells would promote tumor growth, and whether IFN-γ sensitivity could be restored.
Methods: Spontaneous and colitis-associated CRC development was induced in mice with a specific IFN-γ pathway inhibition in intestinal epithelial cells.
Stem cells are fundamental units of tissue remodeling whose functions are dictated by lineage-specific transcription factors. Home to epidermal stem cells and their upward-stratifying progenies, skin relies on its secretory functions to form the outermost protective barrier, of which a transcriptional orchestrator has been elusive. KLF5 is a Krüppel-like transcription factor broadly involved in development and regeneration whose lineage specificity, if any, remains unclear.
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