[The study of preimplantation development of mice embryos labelled with green fluorescent protein gene (EGFp)].

One of the crucial problems of developmental biology is the study of mechanisms of regulation of gene expression in early embryogenesis. Here we studied dynamics of mosaic appearance of a marker fluorescent protein in in vitro developing mice embryo derived from zygotes after microinjections to male pronuclei of cloned DNA fragment carrying EGFP under control of different promoters. Main attention was paid to initial stages of development, when structural rearrangements and reprogramming of both parental genomes, activation of zygotic genes, and control of development by embryo genome take place.

[Activation of a trans-activating factor of NF1 transcription in a lactating mammary gland].

Functional differentiation of a bovine mammary gland in the course of lactation is characterized by significant increase of tissue-specific expression of genes encoding milk proteins (caseins, lactoglobulin etc.). The NF1 is known as a ubiquitous transcription factor which modulates a tissue-specific transcription of different genes (including beta-casein) cooperating with tissue-specific and other ubiquitous transcription factors.