[Hemostasis in patients with systemic skin diseases].

Examinations of the hemostasis system parameters in patients with scleroderma, psoriatic arthritis, malignant lymphoma of the skin have revealed a significant elevation of fibrinogen concentration, acceleration of blood clotting time, increased prothrombin consumption in all the patients. Elevation of the prothrombin index was detected in the patients with scleroderma and psoriatic arthritis. A direct relationship between the disease severity, size of the involvement of the skin integument, inflammation activity in the joints, and severity of hemostasis impairment has been revealed.

[The prognosis of the course of psoriasis].

Analysis of the informative value of signs and prognostic coefficients for 35 clinical amnestic and laboratory parameters helped make up a prognostic table for the assessment of the severity of psoriasis course and therapy efficacy. After consecutive Wald's processing 28 signs were selected out of these 35. The prognostic threshold was calculated, that permitted distribution of the patients into groups with favorable and unfavorable course of psoriasis.

[The treatment of scleroderma with the enzyme preparation collalysine].

Examinations of 42 patients with local scleroderma have revealed increased hydroxyproline and glycosaminoglycane excretion and impaired cellular and humoral immunity, these shifts correlating with the type and severity of the disease. Collalysin therapy resulted in a good clinical effect and improvement of the immune and metabolic parameters.