[The comparative characteristics of cranioplasty methods using biological materials].

Comparative results were obtained in the experiments conducted on dogs in cranioplasty using allogenic bones, one-piece or small-fragmentized brephoxenotransplants. It was found out that allogenic bones and brephoxenotransplants, when conserved in the solution of 0.2% of formaline and 0.

[Osteoplasty in wound infection].

The outcome of a surgical intervention in the purulent wound together with other common clinical factors depends to a determining degree on the quality of the plastic material and its resistance to infection. The authors used allogenic transplants and demineralized bone matrix which had been conserved in solutions of aldehydes and was characterized by high bacteriostatic activity with reduced antigen properties and preservation of its biologic value. This allowed to perform reconstructive operations in 68 patients and to obtain positive results in 89.

[Optimization of conservation regimes and processes of regeneration of organs and tissues in surgery and transplantology using mathematical methods of planning experiments].

The experience of using mathematical planning of an experiment in solving problems of multifactor optimisation in surgery and transplantology is discussed, including optimisation of heart and bone tissue preservation with low-dose aldehydes and antioxidants, study of the effects of retabolil on gastroenteroanastomosis regeneration, and optimisation of ischaemic damage prevention with low-dose aldehydes. In solving these problems, multifactor economical plans were initially applied to identify the optimal variants for several outputs. Second-order plans were further employed to specify the optimal regimes and construct models describing the optimum region.