Publications by authors named "S I Bohlega"
Introduction: The emergence of high-efficacy disease-modifying therapies (HE DMT) for multiple sclerosis (MS) may pose challenges to the administration and monitoring burden of the therapies. This article presents the results of the Delphi consensus method to generate insights from experts on the administration and monitoring burden of HE DMT in Saudi Arabia with a special focus on cladribine.
Methods: Between January and March 2023, a two-round modified Delphi method was used to establish consensus regarding the administration and monitoring burden of HE DMTs used for MS.
With evolving diagnostic criteria and the advent of new oral and parenteral therapies for Multiple Sclerosis (MS), most current diagnostic and treatment algorithms need revision and updating. The diagnosis of MS relies on incorporating clinical and paraclinical findings to prove dissemination in space and time and exclude alternative diseases that can explain the findings at hand. The differential diagnostic workup should be guided by clinical and laboratory red flags to avoid unnecessary tests.
View Article and Find Full Text PDFArticle Synopsis
- * In movement disorders, clinicians' observations are vital for understanding the varied occurrences and symptoms throughout a patient's day and disease progression.
- * The Movement Disorders in Asia Task Force aims to enhance research collaboration by reviewing nine movement disorders first described in Asia, honoring the contributions of early neurologists and scientists.
Article Synopsis
- PDE10A regulates body movements through cyclic adenosine monophosphate signaling in the basal ganglia, with distinct mutations linked to different clinical presentations.
- Autosomal recessive mutations in the GAF-A domain cause infantile onset chorea and developmental delays, whereas dominant mutations in the GAF-B domain lead to childhood onset chorea but with typical cognitive development.
- In a studied family with PDE10A mutations, individuals exhibited recessive symptoms alongside a bi-allelic GAF-B mutation, indicating unique mechanisms affecting PDE10A activity and enhancing our understanding of PDE10A-related movement disorders.
Tremor in Parkinson's Disease: From Pathophysiology to Advanced Therapies.
Tremor Other Hyperkinet Mov (N Y)
October 2022
Background: Tremor is one of the most prevalent symptoms in Parkinson's Disease (PD). The progression and management of tremor in PD can be challenging, as response to dopaminergic agents might be relatively poor, particularly in patients with tremor-dominant PD compared to the akinetic/rigid subtype. In this review, we aim to highlight recent advances in the underlying pathogenesis and treatment modalities for tremor in PD.
View Article and Find Full Text PDF