Publications by authors named "S I Barbour"
Article Synopsis
- * This research analyzed data from 1912 patients over an average of 6.8 years, discovering that corticosteroids did not significantly increase cardiovascular risk, but higher doses of calcineurin inhibitors and certain antimetabolites were linked to greater risks.
- * The study highlights that different immunosuppressive treatments carry varying cardiovascular risks, which should be a crucial factor in choosing therapy for patients with glomerular disease.
Background: B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) play key roles in the pathogenesis of IgA nephropathy. Atacicept is a novel fully humanized fusion protein, self-administered at home by subcutaneous injection, that binds and inhibits BAFF and APRIL. By inhibiting BAFF and APRIL, atacicept targets the underlying B-cell–mediated pathogenesis driving disease progression.
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- * In a study involving 947 children with IgAN, the revised tool outperformed the original in terms of model fit and predictive accuracy for 4-year outcomes, showing enhanced calibration and statistical values.
- * The findings indicated that kidney function (eGFR) trajectories were non-linear, with higher-risk children showing a faster decline, suggesting that the updated prediction should be used for ongoing risk assessment after one or two years following biopsy.