Publications by authors named "S I Baĭborodin"
Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin from a female woolly mammoth (†Mammuthus primigenius) that died 52,000 years ago retained its ancient genome architecture. We use PaleoHi-C to map chromatin contacts and assemble its genome, yielding 28 chromosome-length scaffolds.
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- High biological activity of natural furocoumarins can lead to harmful side effects, like genotoxicity, making it important to develop safer semi-synthetic alternatives.
- The researchers previously examined twenty-one modified furocoumarins to find alterations that reduce negative effects while keeping or improving their beneficial properties.
- In this article, they focus on assessing the cytotoxic activity of these compounds, ranking them by severity, and using statistical analysis to identify the best modifications for future development.
Free heme is a highly toxic molecule for a living organism and its detoxification is a very important process, especially for carnivorous animals. Here we report the discovery of a previously unknown process for neutralizing free heme in the digestive tract of domestic cats. The cornerstone of this process is the encapsulation of heme into carbonated hydroxyapatite nanoparticles, followed by their excretion with faeces.
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- The study investigates how different organic ligands in rhenium cluster complexes affect their biological properties, focusing on cytotoxicity and how they enter and localize within cells.
- The researchers synthesized and characterized four new rhenium clusters using 1,2,3- and 1,2,4-triazoles, and compared their effects with those using benzotriazole, specifically in cervical cancer (HeLa) and human fibroblast (CRL-4025) cell lines.
- Findings suggest that benzotriazole's hydrophobic characteristics enhance the cellular uptake of rhenium clusters, leading to stronger binding to DNA and increased cytotoxicity.
Fluorescent labeling is a widely-used approach in the study of intracellular processes. This method is becoming increasingly popular for studying small bioactive molecules of natural origin; it allows us to estimate the vital intracellular changes which occur under their influence. We propose a new approach for visualization of the intracellular distribution of triterpene acids, based on fluorescent labeling by fluoresceine isothiocyanate.
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