Publications by authors named "S I Alekseenko"
The use of glycerolates of biogenic elements as biocompatible precursors in sol-gel synthesis is an innovative direction and opens up new scientific and practical prospects in chemistry and technology of producing practically important biomedical materials, including hemostatic, antimicrobial, and wound healing materials. Using biocompatible precursors, silicon, zinc, boron, and iron glycerolates, new bioactive nanocomposite hydrogels were obtained by the sol-gel method. The composition and structural features of the hydrogels were studied using a complex of modern analytical techniques, including TEM, XRD, AES, and ESI MS.
View Article and Find Full Text PDFPrevalence and Clinical Impact of Viral and Bacterial Coinfections in Hospitalized Children and Adolescents Aged under 18 Years with COVID-19 during the Omicron Wave in Russia.
Alexander S Yakovlev Vladislav V Afanasev Svetlana I Alekseenko Ilmira K Belyaletdinova Ludmila N Isankina
Viruses
July 2024
Article Synopsis
- * A study in Russia examined 574 hospitalized children under 18 with COVID-19 from January 2022 to March 2023, finding about one-third had coinfections, predominantly adenovirus and bacterial infections.
- * Results indicated that while viral coinfections led to higher fevers and bronchitis, bacterial coinfections resulted in longer illnesses and increased pneumonia, suggesting that seasonal viruses may have been more harmful to children during the Omicron wave than SARS-CoV-2 alone.
Article Synopsis
- Primary ciliary dyskinesia (PCD) is a rare genetic disorder that affects cilia movement, leading to chronic respiratory issues, infertility, and laterality defects in about half of the cases; however, genetic understanding in the Russian population is limited.
- This study analyzed 21 Russian families with PCD, using advanced techniques to confirm ciliary anomalies and discover genetic variants in several PCD-related genes, including both common mutations and novel variants likely unique to Russian individuals.
- The research identified specific mutations that affect gene splicing, with one variant (c.2052+3G>T) linked to an ancestral founder mutation in the Udmurt population, highlighting the significance of regional genetic studies in understanding PCD.
Article Synopsis
- A study examined how different reasons for testing for Helicobacter pylori (H. pylori) affect treatment prescriptions and their success rates across Europe from 2013 to 2023.
- Out of 53,636 cases, the most common reasons for testing included dyspepsia with normal endoscopy and various types of ulcers, with treatment effectiveness ranging from 87% to 91% based on the indication.
- Patients with ulcers and preneoplastic lesions experienced higher treatment success and compliance, while those tested for dyspepsia had higher rates of adverse effects.
Role of proton pump inhibitors dosage and duration in Helicobacter pylori eradication treatment: Results from the European Registry on H. pylori management.
Manuel Pabón-Carrasco Alma Keco-Huerga Manuel Castro-Fernández Ilaria Maria Saracino Giulia Fiorini Sergey Alekseenko
United European Gastroenterol J
February 2024
Article Synopsis
- - The management of Helicobacter pylori infection involves a combination of proton pump inhibitors (PPIs) and antibiotics to effectively eradicate the bacteria, as evaluated by the European Registry on Helicobacter pylori management (Hp-EuReg).
- - Analysis of data from 36,579 patients across five countries revealed that 14-day treatments with specific antibiotic combinations and high-dose PPIs resulted in optimal effectiveness, while 10- and 14-day therapies with high-dose PPIs were also successful.
- - The study concludes that for first-line treatment, the use of high-dose PPIs is recommended, especially in certain combinations and durations, while shorter 7-day therapies showed suboptimal results.