Publications by authors named "S Hutter"
Article Synopsis
- Myeloproliferative neoplasms (MPN) are diverse blood disorders with abnormal blood cell production and a risk of progressing to severe phases, such as blast phase.
- The WHO 2022 categorization recognizes distinct MPNs like chronic myeloid leukemia and others, but diagnosing these conditions can be tricky due to overlapping features and missing clinical information.
- A new model based on 12 genetic markers has been created to help accurately classify MPN patients; it shows that genetic mutations can change as the disease progresses, emphasizing the need for enhanced genetic testing at both diagnosis and during disease advancement.
Gestational diabetes mellitus (GDM) is a common condition during pregnancy. The prevalence of GDM is continuously increasing worldwide. Due to accessible diagnostic methods and a clear understanding of risk factors, GDM can be effectively diagnosed and managed.
View Article and Find Full Text PDFArticle Synopsis
- * Research on pediatric CML revealed that about 60% of young patients have germline variants, primarily in genes like ASXL1, NOTCH1, KDM6B, and TET2, while adult patients show fewer such variants.
- * This study suggests that these germline variants may work together with the BCR::ABL1 oncogene to increase the risk of developing CML in children, potentially triggering the disease at an earlier age.
Article Synopsis
- A series of 61 thiazolidine-2,4-dione compounds with a styryl group was synthesized, analyzed for structure, and tested for their effectiveness against the kinetoplastid parasite and HepG2 cells.
- Some compounds, particularly those with a nitro group, showed promising antileishmanial activity, with one compound demonstrating a low EC of 7 µM and low toxicity in human cell lines.
- Mechanistically, this effective compound is identified as a prodrug activated by nitroreductase 1, producing cytotoxic metabolites that damage the parasite, while maintaining favorable lipophilicity and water solubility.