Migraine in older adults.

Migraine is an evolving, and sometimes lifelong disorder. The prevalence of episodic migraine peaks among individuals aged in their late 30s, implying a tendency for the disorder to remit with increasing age thereafter, whereas chronic migraine is more likely to persist into later life. Diagnosis and treatment of migraine in older adults, defined as individuals aged 60 years or older, is rendered more complex by increasing probabilities of atypical clinical features and comorbidities, with patients' comorbidities sometimes limiting their therapeutic options.

Distribution patterns of occlusal contact areas on natural posterior teeth - Evaluations of a cross-sectional population-based study with the Greifswald Digital Analyzing System (GEDAS).

Aim: The aim of our investigations is to optimize the anatomical basis for the design of a sufficient occlusal relationship, especially in view of the innovative technologies by analyzing the occlusal contact point patterns at cusp structures according to A-, B-, C- localization tooth by tooth on the individual occlusal surfaces in the posterior region in static habitual occlusal position.

Materials And Methods: In 3300 subjects of the population-based Study of Health in Pomerania (SHIP 1) the interocclusal registration in habitual intercuspation using silicone registration was used and analyzed by using the special evaluation software Greifswald Digital Analyzing System (GEDAS II). Chi square test was used to investigate whether the distribution of contact areas differed in the group of premolars or molars - each considered separately for maxilla and mandible - on the basis of the probability of error p < 0.

Real-world long-term efficacy and safety of erenumab in adults with chronic migraine: a 52-week, single-center, prospective, observational study.

Background: Clinical trials have shown that erenumab is effective and well-tolerated for the preventive treatment of chronic migraine. To extend the results from clinical trials, we assessed the real-world efficacy and safety of erenumab in patients with chronic migraine from the outpatient clinic at the Danish Headache Center.

Methods: A 52-week, single-center, prospective, observation study of erenumab in adults with chronic migraine who are eligible for treatment with monoclonal antibodies against CGRP or its receptor in Denmark.

Mid-IR sensing platform for trace analysis in aqueous solutions based on a germanium-on-silicon waveguide chip with a mesoporous silica coating for analyte enrichment.

A novel platform based on evanescent wave sensing in the 6.5 to 7.5 µm wavelength range is presented with the example of toluene detection in an aqueous solution.