Publications by authors named "S Hoyer"
Background: While IL-23 inhibitors, which include guselkumab, tildrakizumab, and risankizumab, are currently FDA-approved solely for the treatment of psoriasis, several other inflammatory skin conditions have been associated with elevated IL-23 levels. The purpose of this review is to summarize and interpret the literature surrounding the off-label uses of IL-23 inhibitors in dermatologic practice.
Methods: We conducted searches on PubMed and for clinical trials, observational studies, case series, and case reports assessing use of the three IL-23 inhibitors for non-psoriatic dermatologic conditions.
We describe a case in which a type 1 Gaucher patient developed ichthyosis weeks after starting substrate reduction therapy (SRT) with eliglustat. There are no reports of ichthyosis in the literature in enzyme replacement or SRT for Gaucher disease. Ichthyosis is seen with type 2 and 3 Gaucher disease, but not type 1.
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- General circulation models (GCMs) are essential for weather and climate predictions, combining physics-based simulations with small-scale process representations like cloud formation.
- Recently, machine learning models have shown they can compete with GCMs for short-term weather forecasting but lack stability for long-term predictions.
- The newly developed NeuralGCM merges a differentiable atmospheric dynamics solver with machine learning, achieving competitive forecasts for both weather and climate while being more computationally efficient than traditional GCMs.
Background: Sleep is essential in the process of memory consolidation. Children and adolescents with epilepsy hold a significantly higher risk for memory impairment. Understanding the relationship between sleep and memory impairment in adolescents with epilepsy will help us to develop effective support services for this patient population.
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