Long Nights, Airplanes, and Avian Surgery: A Tale of Working With Volunteers to Study Long-tailed Ducks () Wintering on Lake Michigan.

Evidence suggests that wintering populations of long-tailed ducks along the Atlantic and Pacific coasts are in decline, but little is known about wintering populations on Lake Michigan. Researchers seek answers to basic questions regarding habitat use and migration patterns (temporal and spatial) of long-tailed ducks that winter on Lake Michigan, by using surgically implanted satellite transmitters. The processes of locating the birds, capturing and implanting satellite transmitters, and interpreting the results were challenging, and efforts relied on dedicated researchers, veterinarians, resource managers, and many volunteers.

Patterns of mercury and selenium exposure in minnesota common loons.

Common loons (Gavia immer) are at risk of elevated dietary mercury (Hg) exposure in portions of their breeding range. To assess the level of risk among loons in Minnesota (USA), we investigated loon blood Hg concentrations in breeding lakes across Minnesota. Loon blood Hg concentrations were regressed on predicted Hg concentrations in standardized 12-cm whole-organism yellow perch (Perca flavescens), based on fish Hg records from Minnesota lakes, using the US Geological Survey National Descriptive Model for Mercury in Fish.

[Comparison of RECIST 1.1 and iRECIST for Response Evaluation in Solid Tumours].

Background: Immunotherapy is a relatively new and developing modality in oncological treatment, which may significantly improve treatment results for some patients with malignant tumors. With the increasing number of clinical trials, the demand for a suitable tool to assess and compare treatment responses is growing. Currently, the most common response assessment system for solid tumors is RECIST (response Evaluation Criteria in Solid Tumors) version 1.

4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain.

In the literature, the introduction of fluorine into bioactive molecules has been known to enhance the biological activity relative to the parent molecule. Described in this article is the synthesis of 4R-fluoro-L-NIL (12) and 4,4-difluoro-L-NIL (23) as part of our iNOS program. Both 12 and 23 were found to be selective iNOS inhibitors as shown in Table 2 below.