Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows.

Low fertility in cows leads to early removal from herds. Since reproductive traits are complex and have low heritability, genetic analysis can aid in improving reproduction. This study identified key genes linked to fertility by conducting genome- and transcriptome-wide association studies, RNA-seq analysis, meta-analysis, weighted gene co-expression network analysis, and functional enrichment analysis.

Encapsulation of AD-MSC- derived extracellular nanovesicles in an electrospun three-layer scaffold: characterization and controlled release analysis.

The combining of therapeutic agents with electrospun nanofibers boosts their regeneration potential; therefore, Researchers have increasingly turned towards the development of electrospun nanofiber scaffolds to encapsulate or surface-adsorb biological payloads, such as cytokines, exosomes, peptides, nucleic acids, and enzymes. Due to their high surface-to-volume ratio, ease of manufacturing, and drug-loading capacity, electrospun nanofibers are hopeful in tissue engineering and scaffold fabrication. Electrospun multilayer scaffolds offer a promising construction for preserving the integrity and bioactivity of therapeutic factors while permitting the controlled and prolonged release of biomolecules into the environment.

Reliability of the Wii balance board for static and dynamic balance assessment in total knee arthroplasty patients.

Purpose: Poor performance in practicing balance tasks is partly caused by the changes in the knee function and balance control activities following total knee arthroplasty (TKA). The purpose of this study was to determine the test-retest reliability of the static and dynamic balance measures using Wii Balance Board (WBB) in patients after TKA.

Design: Thirty-one TKA patients (6 males, 27 females, mean age 55 ± 5.

Engaging children and adolescents in the design and conduct of paediatric research.

The importance of patient engagement in product development and clinical research is widely acknowledged. In pediatrics, parents and guardians are often vocal advocates for their children in the process, but investigators and sponsors rarely directly solicit children's or adolescents' perspectives in clinical research planning or as patient partners during the conduct of research. Here, we provide compelling reasons and recommendations for investigators and sponsors to systematically engage young people in the design, conduct, and review of research, and the premise that input will be incorporated as a routine expectation.