Factors associated with scoliosis development in patients with congenital diaphragmatic hernia: A single-center retrospective study.

Background: Scoliosis is the most frequent complication of musculoskeletal abnormalities in patients with congenital diaphragmatic hernia, but the factors that related to its development and severity remain largely unknown. This study aimed to investigate the clinical factors associated with the development and severity of scoliosis in patients with congenital diaphragmatic hernia.

Methods: Thirty-two patients admitted to the neonatal intensive care unit for congenital diaphragmatic hernia at the University of the Ryukyus Hospital between 2004 and 2019 were retrospectively analyzed, particularly those who were discharged alive and had available chest radiographs at 4-5 years of age from medical records.

Progressive changes in delivery outcomes following the launch of round-the-clock labour epidural analgesia at an institution: A retrospective cohort study.

Background: Emergency caesarean section is associated with maternal and foetal complications, potentially exacerbated by general anaesthesia use.

Objective: To determine whether labour epidural analgesia use affects caesarean section incidence.

Study Design: This retrospective single-centre cohort study involved women in labour (n = 11,792) between 1 January 2015 and 31 December 2021.

Pitfalls of the E-Ref Procedure: Tie Values and the Proportion of the Abnormal Data.

Introduction: Extrapolated reference values (E-Ref) procedure is a new method for determining the cutoff value without collecting the control data. We tried to apply this method to determine the cutoff value for the distal motor latency of the median nerve (median DML). During this process, we found two pitfalls of the E-Ref method.

Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts.

Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left ventricular reverse remodeling (LVRR). Currently, the detailed association between genotypes and clinical outcomes, including LVRR, particularly among children, remains uncertain.

The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in adipocytes.

White adipocytes are a major component of white adipose tissue (WAT) and help to maintain systemic metabolic homeostasis by storing energy and secreting adipokines. In mice deficient in the protein WWP1 (WW domain-containing E3 ubiquitin protein ligase 1), oxidative stress in adipocytes increases but insulin resistance induced by obesity improves. However, the specific roles of WWP1 in adipocytes remain unclear.