Publications by authors named "S Horita"
Article Synopsis
- * Factors linked to elevated IgG4 included male sex, older age, lower lipid and polyunsaturated fatty acid intake, and higher carbohydrate intake in both genders, with additional specific associations for men related to kidney function and blood sugar levels.
- * The findings suggest that elevated serum IgG4 levels are connected to age, gender, and diet, which may reflect similar patterns seen in IgG4-related disease (IgG4-RD).
Purpose: To evaluate the safety, pharmacokinetics, and exploratory efficacy of tivozanib eye drops in healthy volunteers and patients with neovascular age-related macular degeneration (nAMD).
Design: This multicenter group-sequential dose escalation phase I study consisted of a placebo-controlled double-masked study of healthy volunteers (cohorts 1 and 2) and an open-label study of patients with nAMD (cohort 3).
Participants: Healthy volunteers: Japanese or White men aged 20 to <50 years.
Article Synopsis
- Intrarenal dopamine helps protect against diabetic nephropathy in early-stage diabetes by reducing glomerular hyperfiltration, oxidative stress, inflammation, and fibrosis in mice models.
- The study used benserazide to investigate the effects of peripheral dopamine on kidney function in spontaneously diabetic Torii rats, showing that lower peripheral dopamine levels worsen renal dysfunction.
- Findings reveal that peripheral dopamine plays a crucial role in controlling oxidative stress and kidney performance during the early stages of diabetic nephropathy, evidenced by its effect on markers of renal dysfunction.
Reports of cold agglutinin disease (CAD), an autoimmune hemolytic anemia, in dialysis patients are limited. Recently, sutimlimab for CAD was covered by insurance. Herein, we report a case in which sutimlimab was effective in the treatment of CAD in a patient undergoing hemodialysis (HD).
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