Publications by authors named "S Hitomi"
Introduction: We investigated clinical and microbiological characteristics of invasive Haemophilus influenzae disease (IHD) during recent 20 years in the Minami Ibaraki Area.
Methods: H. influenzae strains isolated from the blood and the cerebrospinal fluid in 5 hospitals located in this area between 2001 and 2020 (the pre-vaccination period [PreVP]: 2001-2010, the post-vaccination period [PostVP]: 2011-2020) were consecutively collected.
Objectives: The underlying mechanism of masseter muscle pain hypersensitivity by sustained masseter muscle contraction (SMMC) is not well understood. This study aimed to examine whether the activation of satellite glial cells in the trigeminal ganglion (TG) contributes to masseter muscle pain hypersensitivity induced by SMMC.
Methods: Electrodes were placed on the masseter muscle fascia of rats to induce strong contractions, by daily electrical stimulation.
Article Synopsis
- Prolonged nephrostomy tube use can lead to nephrostomy tube-associated pyelonephritis (NTAP) in patients with malignancies, but data on NTAP characteristics in this group are limited.
- A study analyzed 43 NTAP cases, identifying causative microorganisms primarily as E. coli and Klebsiella pneumoniae, with specific non-causative organisms like certain enterococci and Candida species.
- Treatment with antimicrobials for 7 days resulted in recovery for most patients, indicating that not all detected microorganisms require immediate treatment, particularly those resistant to cephalosporins.
Damage to the peripheral nerves of trigeminal ganglion (TG) neurons leads to intractable orofacial neuropathic pain through the induction of neuroinflammation. However, the details of this process are not yet fully understood. Here, we found that fibroblast-derived interleukin (IL)-33 was required for the development of mechanical allodynia in whisker pad skin following infraorbital nerve injury (IONI).
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- Age-related changes in macrophage polarization in the trigeminal ganglion (TG) contribute to increased sensitivity to intra-oral pain after mucosal incisions, particularly in older SAMP8 mice compared to younger SAMR1 mice.
- The study involved measuring pain thresholds and analyzing the presence of specific inflammatory macrophage types (M1 and M2) in the TG over a period of 21 days post-injury.
- Results showed that enhanced CCL2 signaling from M1-macrophages in older mice led to greater pain hypersensitivity, indicating a link between aging, macrophage activity, and prolonged pain response.