[Implementation of the guidelines on the prevention of violence and coercion: pre-post analysis of the randomized controlled PreVCo study].

Aim Of The Study: This study examines the extent to which a structured implementation of guidelines for the prevention of coercion leads to an improvement in guideline-compliant work and the reduction of coercion in routine clinical practice.

Methods: This is a secondary analysis of the shift of outcomes in the PreVCo study, which was conducted on 55 psychiatric wards throughout Germany.

Results: The number of coercive measures decreased significantly during the observation period.

Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors.

Background: Atypical teratoid rhabdoid tumors (ATRT) are incurable high-grade pediatric brain tumors. Despite intensive research efforts, the prognosis for ATRT patients under currently established treatment protocols is poor. While novel therapeutic strategies are urgently needed, the generation of molecular-driven treatment concepts is a challenge mainly due to the absence of actionable genetic alterations.

Performance and safety evaluation of a cold ablation robot-guided laser osteotome (CARLO) in 28 midface osteotomies.

The CARLO (cold ablation robot-guided laser osteotome) is a compact device with integrated multiple sensory, steering and safety checking elements. A multi-center study was performed to evaluate the CARLO device for the linear part of midface osteotomy in 28 patients. Feasibility, success rate, safety, performance and experience of the surgeons were assessed and evaluated.

Enhanced antifungal activity of siRNA-loaded anionic liposomes against the human pathogenic fungus .

We developed siRNA-loaded anionic liposomes, co-encapsulating low-dose amphotericin B, to enhance siRNA penetration through the fungal cell wall of . Targeting mRNAs of three key genes, these liposomes visibly inhibited fungal growth, demonstrating for the first time the antifungal potential of siRNA against human fungal pathogens.