Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

Right middle occipital gyrus is associated with egocentric spatial orientation during body tilt: Evidence from a repetitive transcranial magnetic stimulation study.

Accurate perception of the orientation of external objects relative to the body, known as egocentric spatial orientation, is fundamental to performing action. Previously, we found via behavioural and magnetic resonance imaging voxel-based morphometry studies that egocentric spatial orientation is strongly distorted when the whole body is tilted with respect to gravity, and that the magnitude of this perceptual distortion is correlated with the grey matter volume of the right middle occipital gyrus (rMOG). In the present study, we further validated the association between the neural processing in the rMOG and the perceptual distortion by transiently suppressing neural activity in this region using low-frequency repetitive transcranial magnetic stimulation (rTMS) and evaluating the consequent effect on perceptual distortion.

Immune-related adverse event detection in liver cancer patients treated with immune checkpoint inhibitors: Nationwide exploratory survey in Japan.

Aim: This study aimed to comprehensively assess the incidence of immune-related adverse events (irAEs) and the detection systems in place for patients with liver cancer undergoing treatment with immune checkpoint inhibitors (ICIs), using a self-administered anonymous questionnaire. The questionnaire was designed to gather crucial insights into the management of irAEs in these patients.

Methods: A self-administered anonymous questionnaire was sent to 456 liver disease collaborative base hospitals and cancer care coordination base hospitals in Japan.

pH-Dependent migratory behaviors of neutrophil-like cells in a microfluidic device with controllability of dissolved gas concentrations.

Inflammatory microenvironments often become acidic (pH < 7.4) due to tissue oxygen deprivation and lactate release in glycolysis by activated immune cells. Although neutrophils are known to accumulate in such microenvironments, the effects of pH on their migration are not fully understood.

Impact of Atezolizumab + Bevacizumab Therapy on Health-Related Quality of Life in Patients with Advanced Hepatocellular Carcinoma.

Background/objectives: Health-related quality of life (HRQoL) is critical in patients with hepatocellular carcinoma (HCC). It has become a key endpoint in the evaluation of new therapies, including atezolizumab + bevacizumab (Atezo + Bev) therapy.

Methods: This study explored the factors associated with treatment efficacy, treatment duration, and overall survival (OS) in patients with advanced HCC undergoing Atezo + Bev therapy.