Publications by authors named "S Hiratsuka"
Background: Pseudarthrosis is a major complication after posterior lumbar interbody fusion (PLIF) and transforaminal interbody fusion (TLIF), and its risk factors need to be identified. This study aimed to investigate the relationship between the number of remaining teeth (NRT) and pseudarthrosis.
Methods: NRT, preoperative bone density of the proximal femur (percentages of young adult mean; % YAM), and preoperative procollagen type 1 N-terminal propeptide (P1NP) (μg/L) were retrospectively investigated in 63 patients (24 male and 39 female, mean age: 71.
Article Synopsis
- * MALIF was tested on 15 patients suffering from lumbar spondylolisthesis, resulting in a mean surgery time of about 97 minutes, minimal blood loss, and short hospital stays, with most patients experiencing symptomatic improvement.
- * The technique provides three main benefits: enhanced access to the surgery site, precise discectomy, and improved safety for the nerve root, indicating that MALIF could be a viable minimally invasive surgery option.
Article Synopsis
- The Jones fracture is a common injury among soccer players, typically resulting from excessive stress on the fifth metatarsal during actions like crossover cutting.
- This study examined how hip internal rotation (HIR) and foot progression angle (FPA) influence the forces on the fifth metatarsal during this movement in 20 experienced male soccer players.
- Findings revealed no link between HIR and plantar pressure on the metatarsal, but a higher FPA was associated with lower plantar pressure, suggesting that adjusting FPA during crossover cutting could help prevent Jones fractures.
The μ-opioid receptor (MOR) is a G-protein-coupled receptor (GPCR) that mediates both analgesic effects and adverse effects of opioid drugs. Despite extensive efforts to develop a signal-biased drug, drugs with sufficiently reduced side effects have not been established, in part owing to lack of comprehensive signal transducer profiles of MOR. In this study, by profiling the activity of signal transducers including G proteins and GPCR kinases (GRKs), we revealed an unprecedented mechanism of selective GRK3 activation by Gβ, leading to β-arrestin recruitment.
View Article and Find Full Text PDFA long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca in living cells is exclusive to Gq- and Gi-sensitive G protein-coupled receptors (GPCRs). Here we extend this central tenet and show that Gs-GPCRs also partake in inositol-lipid signaling and thereby increase cytosolic Ca. By combining CRISPR/Cas9 genome editing to delete Gα, the adenylyl cyclase isoforms 3 and 6, or the PLCβ1-4 isozymes, with pharmacological and genetic inhibition of Gq and G11, we pin down Gs-derived Gβγ as driver of a PLCβ2/3-mediated cytosolic Ca release module.
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