Publications by authors named "S Hickmann"
Evaluation of clinical and microbiological factors related to mortality in patients with Gram-negative bacterial infections treated with ceftazidime-avibactam: A prospective multicentric cohort study.
J Glob Antimicrob Resist
March 2024
Objectives: This study aimed to evaluate the clinical and microbiological risk factors associated with mortality in patients treated with ceftazidime-avibactam for carbapenem-resistant Gram-negative bacterial infections.
Methods: This multicentric prospective cohort study included hospitalized adult patients with a microbiologically confirmed infection treated with ceftazidime-avibactam for ≥48 hours. The clinical and microbiological risk factors for 30-day mortality were evaluated using a Cox regression model.
Article Synopsis
- The study aimed to assess the quality of referrals for first Rheumatology consultations in Porto Alegre, Brazil, comparing results from a previous survey in 2007/2008 with current findings post-implementation of new referral protocols and teleconsulting systems.
- A total of 357 patient cases were analyzed over a six-month period, recording demographic data and diagnostic suspicions, focusing on the identification of systemic autoimmune inflammatory diseases (SIRD).
- Results showed a significant increase in suspected SIRD diagnoses for both capital and outlying regions, particularly highlighting improved referral quality in areas using the new triage system, indicating positive changes over the past decade.
Background: Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from purine metabolism. Oxidative stress is an important factor related to endothelial dysfunction and ischemia-reperfusion injury, and may be implicated in the pathogenesis of heart failure, hypertension, and ischemic heart disease. However, there is contradictory evidence regarding the possible cardiovascular (CV) protective effect exerted by XOI.
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