Publications by authors named "S Hessey"
Article Synopsis
- - The study introduces the SPRINTER algorithm, which analyzes single-cell DNA sequencing to identify and classify the proliferation rates of different cancer cell clones within tumors, shedding light on the variability of cell growth among these clones.
- - Applying SPRINTER to nearly 15,000 non-small cell lung cancer cells showed significant differences in clone proliferation, which was corroborated by various imaging techniques and indicated that more proliferative clones also had a higher likelihood of metastasis and altered genetic replication patterns.
- - The algorithm's effectiveness was further demonstrated in breast and ovarian cancer datasets, where it uncovered higher proliferation rates and genetic variations in specific, more rapidly growing cell clones.
Metastasis is a complex process and the leading cause of cancer-related death globally. Recent studies have demonstrated that genomic sequencing data from paired primary and metastatic tumours can be used to trace the evolutionary origins of cells responsible for metastasis. This approach has yielded new insights into the genomic alterations that engender metastatic potential, and the mechanisms by which cancer spreads.
View Article and Find Full Text PDFLung cancer is the leading cause of cancer-associated mortality worldwide. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome.
View Article and Find Full Text PDFMetastatic disease is responsible for the majority of cancer-related deaths. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis.
View Article and Find Full Text PDF