Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance.

Aims/hypothesis: Metabolic disorders associated with abdominal obesity, dyslipidaemia, arterial hypertension and hyperglycaemia are risk factors for the development of insulin resistance. Extracellular vesicles (EVs) may play an important role in the regulation of metabolic signalling pathways in insulin resistance and associated complications.

Methods: Circulating large EVs (lEVs) and small EVs (sEVs) from individuals with (IR group) and without insulin resistance (n-IR group) were isolated and characterised.

DETECTION AND QUANTIFICATION OF MICROCIRCULATORY DYSFUNCTION IN SEVERE COVID-19 NOT REQUIRING MECHANICAL VENTILATION: A THREE-ARM COHORT STUDY.

Aim: To identify and describe microcirculatory dysfunction (MD) in severe COVID-19 cases. Methods: This prospective, cohort study evaluated microvascular function in COVID-19 patients with acute respiratory failure not requiring mechanical ventilation and compared it with that of non-COVID-19 intensive care unit (ICU)-matched controls. A validation cohort included healthy, comorbidity-free patients.

BEAMER: A Data Informed Model to Improve Adherence Behaviour.

Objective: In this poster, we will present the BEAMER model, an emerging disease-agnostic model to improve adherence behaviour based on actionable factors and promote optimal health outcomes for all.

Methods: Data on behavioural and structural factors affecting adherence to treatment have been collected from several sources and are being used to build the BEAMER model, where we aim to apply Machine Learning Modelling to forecast and diversify support towards more adherent behaviour.

Results: The BEAMER model can assist healthcare providers in eliciting patient needs to adopt targeted actions to support patients in improving their adherence.

Exercise transcutaneous oximetry in functional popliteal artery entrapment syndrome diagnosis.

Introduction: Functional popliteal artery entrapment syndrome is a subtype of popliteal artery entrapment syndrome (PAES) without vascular disease or musculotendinous anomaly behind the knee. Symptoms are induced by popliteal artery extrinsic compression, leading to calf pain during lower limbs exercise. Non-invasive tests are still required to improve the diagnostic management of functional PAES.