Publications by authors named "S Headland"
Article Synopsis
- The study investigates the roles of all four mammalian Argonaute (AGO) proteins in microRNA (miRNA) activity and finds that only AGO2 is essential for miRNA function, while AGO1, AGO3, and AGO4 can be disregarded for this purpose.
- Instead of miRNA regulation, AGO1, AGO3, and AGO4 are shown to influence type 2 immunity through their role in splicing precursor mRNA in CD4 T helper lymphocytes.
- The research highlights a direct interaction between nuclear AGO3 and SF3B3, which is part of the splicing machinery, affecting mRNA splicing and specifically the Nisch gene isoforms, implicating
Article Synopsis
- Exacerbations of asthma symptoms are a major concern, linked to bacterial imbalances and infections that can worsen the condition.
- Research shows that bacterial lipopolysaccharide (LPS) triggers production of oncostatin M (OSM), which is associated with severe asthma and inflammation.
- The study suggests that targeting OSM could be a potential strategy to prevent worsening asthma symptoms linked to bacterial factors.
Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory disease and cancer. Here, we assess the response of immune cells to lactate in the context of chronic inflammation. We report that lactate accumulation in the inflamed tissue contributes to the upregulation of the lactate transporter SLC5A12 by human CD4 T cells.
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- Casearia sylvestris is commonly used in folk medicine for pain relief and this study explores its effects on chronic pain in a mouse model.
- The research involved administering a hydroalcoholic extract of Casearia sylvestris and pro-resolving mediators to mice after inducing pain through ischemia and reperfusion.
- Results showed that the extract and certain natural and synthetic compounds effectively reduced mechanical hyperalgesia, suggesting that the anti-pain effects are linked to the ALX/FPR2 receptor pathway involved in resolving inflammation.