Public Health.

Background: Using a unique natural randomization, we have recently provided evidence from Welsh electronic health record data that herpes zoster (HZ) vaccination caused a reduction in new dementia diagnoses over a seven-year period. This study aimed to determine whether eligibility for HZ vaccination also caused a reduction in deaths due to dementia in England and Wales over a nine-year follow-up period.

Methods: Adults who had their 80 birthday shortly before September 1 2013 were ineligible for free HZ vaccination and remained ineligible for life, whereas those who had their 80 birthday shortly after September 1 2013 (i.

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity.

Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse effects and clinical trial failures. A more feasible approach is to modulate NMDAR activity or calcium signaling indirectly.

Diets, fruit and vegetables consumption, and nutritional status in Benin: A scoping review.

Unhealthy diets, including low fruit and vegetables (F&V) intake, contribute to morbidity and mortality related to non-communicable diseases. Designing culturally appropriate interventions to improve diets and F&V intake requires an in-depth understanding of individual-level dietary patterns, household consumption patterns, and nutritional status resulting from inadequate F&V intake. In this scoping review, we summarised the literature on diets, F&V intake, and nutritional status in Benin.

Diets, Fruit and Vegetable Intake and Nutritional Status Among Children, Adolescents and Adults in the Philippines: A Scoping Review.

Suboptimal diets contribute to the risk of malnutrition and non-communicable diseases across the life course. Globally, intakes of fruit and vegetables (F&V) fall below recommendations, including in the Philippines. To promote F&V intakes, understanding the extent of inadequate intakes across population groups and key drivers of dietary patterns is needed.

Diets, Fruit and Vegetable Intake and Nutritional Status in Tanzania: Scoping Review.

Globally, the intake of fruit and vegetables (F&V) is far below the recommended levels, contributing to various health challenges including micronutrient deficiencies and non-communicable diseases. In Tanzania, where the triple burden of malnutrition persists, there is a need to identify gaps in evidence, better understand diets and F&V intake and identify promising interventions for improved intake. We conducted a scoping review to summarize the evidence on dietary intake, F&V intake and nutritional status in Tanzania.