Publications by authors named "S Hazama"
Reducing recurrence following radical resection of colon cancer without overtreatment or undertreatment remains a challenge. Postoperative adjuvant chemotherapy (Adj) is currently administered based solely on pathologic TNM stage. However, prognosis can vary significantly among patients with the same disease stage.
View Article and Find Full Text PDFRationale: Treatment strategies for rectal squamous cell carcinoma (rSCC) are yet to be established, given its rarity. Although squamous cell carcinoma has been reported to be highly sensitive to cetuximab and radiation, there is no report of combination therapy of cetuximab and radiation for rSCC. In this study, we firstly reported a case of rSCC in which a complete response was achieved with the original chemoradiotherapy comprising oxaliplatin, S-1, cetuximab, and simultaneous radiation.
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- This study investigates the role of serum proteinase-3 (PRTN3) as a potential predictive biomarker for prognosis and responsiveness to chemotherapy, particularly bevacizumab, in patients with metastatic colorectal cancer (mCRC).
- The research included 79 patients and utilized data from the TCGA database, measuring preoperative serum PRTN3 levels and evaluating their association with clinical outcomes and tumor characteristics.
- Results indicated that high serum PRTN3 levels correlated with poorer prognosis and lower sensitivity to first-line chemotherapy and bevacizumab, suggesting that PRTN3 could serve as an independent poor prognostic factor in mCRC patients.
Article Synopsis
- * After four cycles of the combination therapy, the patient's condition showed complete response on imaging, but side effects like eosinophilia and skin disorders developed during the treatment.
- * The treatment was stopped, leading to normalization of eosinophil counts and gradual skin improvement, but after restarting the monotherapy two months later, the side effects recurred, prompting another treatment cessation.
Background: The prognosis for patients with colorectal cancer (CRC) is determined by tumor characteristics as well as the host immune response. This study investigated the relationship between an immunosuppressive state and patient prognosis by evaluating the systemic and tumor microenvironment (TME) interleukin (IL)-6 levels.
Methods: Preoperative serum IL-6 levels were measured using an electrochemiluminescence assay.