Publications by authors named "S Hassanien"
Congenital renal tumors are rare. In infancy, congenital mesoblastic nephroma is the most commonly reported renal tumor. It is recognized antenatally due to polyhydramnios and presents clinically as a palpable abdominal mass in the neonatal period.
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- - The MET receptor is crucial for various biological processes, but its dysregulation is linked to cancers like non-small cell lung cancer and renal cancer, highlighting a significant medical need for better treatment options.
- - Current MET inhibitors face challenges such as resistance and toxicity, particularly in treating brain metastases, which further emphasizes the demand for improved therapies.
- - Researchers are developing a new class of MET inhibitors designed to effectively target brain tumors and specific cancer mutations, which showed promising results in preclinical models, significantly extending survival in treated animals.
Article Synopsis
- - Macrothrompocytopenia (MTP) is a rare hereditary disorder caused by genetic mutations that affect blood clotting, primarily due to dysfunction in megakaryocytes, which are crucial for platelet production
- - The DIAPH1 gene plays a significant role in this disorder, with variants leading to macrothrombocytopenia and associated conditions like sensorineural deafness; different mutations result in varying symptoms including seizures and microcephaly in more severe cases
- - A case study of a 14-year-old Saudi girl highlighted a novel mutation (c.3633_3636del) in the DIAPH1 gene, suggesting its potential link to both MTP and autosomal dominant non-syndromic
Combined factor V and factor VIII deficiency (F5F8D) is an exceedingly rare autosomal recessive disease that causes concomitantly low levels of factor V and factor VIII, leading to mild to moderate bleeding tendencies. Within this disorder, mutations manifest in the lectin mannose-binding protein (LMAN1) or multiple coagulation factor deficiency 2 (MCFD2) genes. This report presents a case of a five-year-old Saudi female child who was referred from an otolaryngology clinic, with an incidental finding of prolonged prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT) detected during routine preoperative investigations for tonsillectomy, prompting further investigations.
View Article and Find Full Text PDFOpioid overdoses, particularly those involving fentanyl-related substances (FRS), present a significant public health challenge in the United States. This structure-activity relationship (SAR) study evaluated the relationship between the chemical structure of seventeen FRS and their in vivo mu-opioid-receptor (MOR) mediated effects. SAR evaluations included fluorine substitutions on the aniline or phenethyl ring and variations in N-acyl chain length.
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