Publications by authors named "S Hardy"

Background: Sickle cell disease (SCD) confers neurological risks that contribute to cognitive and academic difficulties. Clinical guidelines state that cognition should be monitored using signaling questions. However, evidence is lacking regarding the extent to which signaling questions accurately identify children with cognitive issues.

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: People with a severe mental illness die much earlier than the rest of the population from a preventable physical illness. Annual health checks are a way of assessing the person to then offer the appropriate interventions. Integrated Care Northampton, England used the long-term plan baseline funding allocated to them from the government department that commissions primary care services, to implement a local enhanced service.

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Hardy, SGJ, Stelzer-Hiller, OW, Edwards, KM, and Freeston, J. Criterion validity and reliability of a new medicine ball rotational power test. J Strength Cond Res XX(X): 000-000, 2024-This study assessed the validity and reliability of 2 medicine ball rotational power assessments, the novel push for maximum velocity by radar (MB vel ), and the commonly used push for maximum distance by tape measure (MB dis ), against the criterion reference 3-dimensional motion capture (MoCap) to identify the best-practice field-based assessment.

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Objective: Prenatal exome sequencing (pES) for diagnosing fetal structural anomalies commenced in the English National Health Service (NHS) in 2020. We evaluated cost-effectiveness to the healthcare system, and costs to families, of pES in addition to standard testing, compared to standard testing alone.

Design: A cost-effectiveness analysis combining costs, outcomes, parent and professional interview and professional survey data.

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Article Synopsis
  • Prenatal exome sequencing (pES) was introduced in England to improve genetic diagnosis in fetuses with structural anomalies, and the study aimed to analyze its outcomes between October 2021 and June 2022, including diagnostic yield and referral rates.
  • Out of 475,089 births, the pES referral rate was 8.6 per 10,000, with 59% of referred women undergoing testing; 35% of those received a definitive diagnosis, averaging a turnaround time of 15 days.
  • The study found significant variations in outcomes based on diagnostic results, with 40% of women with a definite diagnosis choosing termination of pregnancy, compared to only 18% among those without a diagnosis.
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