Publications by authors named "S Handschuh"
Article Synopsis
- Ex vivo x-ray angiography enables detailed 3D imaging of blood vessels, including capillaries, by using a contrast agent to visualize the vascular structure after blood removal from organs.
- The study introduces advanced microDECT imaging protocols to analyze microvasculature while differentiating it from surrounding tissues, using specific contrast agents and counterstaining techniques.
- New workflows allow for automatic processing of images into distinct channels for skeletal tissue, vasculature, and soft tissue, enhancing the ability to analyze and investigate microvasculature in various research applications.
Ticks are composed of 3 extant families (Argasidae, Ixodidae and Nuttalliellidae) and 2 extinct families (Deinocrotonidae and Khimairidae). The Nuttalliellidae possess one extant species () limited to the Afrotropic region. A basal relationship to the hard and soft tick families and its limited distribution suggested an origin for ticks in the Afrotropics.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the anatomy and imaging techniques for Giant African land snails (GALS), which are gaining popularity as pets and in educational settings in Europe.
- - It explores various diagnostic imaging methods, including radiography, computed tomography, and sonography, to determine the best ways to visualize GALS' mantle cavity organs.
- - The research includes detailed anatomical illustrations but excludes the sensory organs and nervous system from its scope.
Activating the stimulator of interferon genes (STING) pathway with STING agonists is an attractive immune oncology concept to treat patients with tumors that are refractory to single-agent anti-PD-1 therapy. For best clinical translatability and broad application to cancer patients, STING agonists with potent cellular activation of all STING variants are desired. Novel cyclic dinucleotide (CDN)-based selective STING agonists were designed and synthesized comprising noncanonical nucleobase, ribose, and phosphorothioate moieties.
View Article and Find Full Text PDFMultispecific antibodies have gained significant importance in a broad indication space due to their ability to engage multiple epitopes simultaneously and to thereby overcome therapeutic barriers. With growing therapeutic potential, however, the molecular complexity increases, thus intensifying the demand for innovative protein engineering and analytical strategies. A major challenge for multispecific antibodies is the correct assembly of light and heavy chains.
View Article and Find Full Text PDF