One-hoUr Troponin using a high-sensitivity Point-Of-Care assay in emergency primary care: The OUT-POC pilot study.

Introduction Novel point-of-care (POC) high-sensitivity cardiac troponin (hs-cTn) tests could enhance acute myocardial infarction (MI) assessment outside hospital. This pilot study evaluates the efficacy, feasibility, and precision of the QuidelOrtho TriageTrue hs-cTnI POC assay when used by non-laboratory personnel in emergency primary care. Methods A prospective pilot study was conducted from April to June 2024 at the main emergency primary care clinic in Oslo, Norway.

Remnant cholesterol, plasma triglycerides and risk of cardiovascular disease events in young adults: a prospective cohort study.

Aim: To investigate if elevated levels of cholesterol carried in triglyceride-rich lipoproteins, marked by remnant cholesterol or plasma triglycerides, are associated with increased risk of premature cardiovascular disease (CVD) events in young adults.

Methods: Prospective cohort study. In year 2000, all 30-year-old inhabitants living in Oslo, Norway, were invited to the "Oslo Health Study" including a clinical examination and routine blood tests.

Rapid rule-out of acute myocardial infarction using the 0/1-hour algorithm for cardiac troponins in emergency primary care: the OUT-ACS implementation study.

Background: Acute chest pain has a high hospital referral rate due to the limited ability to exclude acute myocardial infarction (MI) in primary care. We aimed to evaluate the effectiveness of implementing the European Society of Cardiology (ESC) 0/1-hour algorithm for high-sensitivity cardiac troponin T (hs-cTnT) testing in emergency primary care.

Methods: In a prospective study (April-October 2023), the ESC 0/1-hour algorithm for hs-cTnT was implemented at the main emergency primary care clinic in Oslo, Norway.

Effect of metoprolol exposure following myocardial infarction on future cardiovascular events: a Mendelian randomization study.

Purpose: The clinical benefit of up-titration of metoprolol to a guideline-recommended target dose after myocardial infarction (MI) is unknown. Our aim was to investigate whether variation in metoprolol exposure determined by cytochrome p450 enzyme 2D6 (CYP2D6) influences the occurrence of major adverse cardiovascular events (MACE) and cardiovascular death (CV death) among patients treated with metoprolol after MI.

Method: This Mendelian randomization study was performed using individual-level data from 1554 patients treated with metoprolol after an acute MI.

Cardiogenic shock in women: From risk factors to therapy.

Cardiogenic shock (CS) in women is a serious cardiovascular (CV) event associated with a high mortality rate. Non-ischemic etiologies are the most common etiologies in women, such as stress-induced cardiomyopathy, peripartum/postpartum cardiomyopathy, heart failure-related CS, or CS due to myocarditis or valvular heart disease. Although not being the most common etiology in women, acute myocardial infarction is still an important one.