Publications by authors named "S Haitjema"
Article Synopsis
- The study examines how impaired liver function affects the toxicity of the anticancer drug paclitaxel, specifically focusing on hematological complications, dose modifications, and overall survival rates in cancer patients.
- It analyzes data from 569 patients treated at the University Medical Centre Utrecht between 2011 and 2022, comparing those with normal and impaired liver function based on specific medical criteria.
- Results show that patients with liver impairment experienced significantly higher risks of severe neutropenia and leukopenia, required more dose modifications, and had poorer overall survival in cases of inoperable esophageal and advanced ovarian cancers.
Despite advances in allogeneic hematopoietic cell transplantation (HCT), poor graft function (PGF) remains an important complication with substantial morbidity and mortality. The investigation of preventive and therapeutic PGF treatments is hindered by inconsistencies in reported incidence and outcomes across studies, which may be explained by heterogeneity in PGF definition. To assess the impact of definition heterogeneity, we conducted a multicenter study, analyzing over 35.
View Article and Find Full Text PDFFederated systems for automated infection surveillance: a perspective.
Stephanie M van Rooden Suzanne D van der Werff Maaike S M van Mourik Frederikke Lomholt Karina Lauenborg Møller Saskia Haitjema
Antimicrob Resist Infect Control
September 2024
Article Synopsis
- Automation of surveillance of infectious diseases can streamline processes and enhance quality but faces implementation barriers.
- The manuscript discusses the pros and cons of two strategies for automated surveillance: centralized and localized systems.
- The concept of federated automated surveillance is proposed as a potential solution to challenges, facilitating better data access, maintaining privacy, and promoting international collaboration in monitoring healthcare-associated infections and severe respiratory illnesses.*
Article Synopsis
- The study investigates how well clinicians accept real-time data imputation to address missing patient data in a clinical decision support system (CDSS) designed for assessing cardiovascular risk.
- Seventeen clinicians evaluated a CDSS using a method called joint modelling imputation (JMI), assessing vignettes that simulated situations with missing data and provided different risk estimates.
- Although the study found JMI useful for educational purposes, clinicians felt uncomfortable with the reliability of imputed predictions, indicating a need for more accurate data imputation for effective use in clinical practice.
Article Synopsis
- - The study examines the relationship between kidney function and echocardiography findings related to left ventricular diastolic dysfunction (LVDD) in patients from a university hospital, categorizing them by levels of kidney function based on estimated glomerular filtration rate (eGFR).
- - Among 4,022 patients, those with increasingly decreased kidney function showed higher odds of having abnormal echocardiographic parameters, including the E/e' ratio and left ventricular mass index (LVMI), indicating a clear connection between deteriorating kidney health and worsening cardiac function.
- - The findings reveal that even mildly decreased kidney function is associated with signs of LVDD, suggesting that as kidney function declines, the risk of echocardiographic abnormalities in