Publications by authors named "S Hahner"
Objective: Cushing's syndrome (CS) results in increased cardiovascular (CV) morbidity and mortality. Subtype-specific differences and possible reversibility after biochemical cure are not well investigated.
Design: Prospective cohort study evaluating the CV status in different forms of endogenous cortisol excess.
Background: High flow nasal cannula (HFNC) has been increasingly adopted in the past 2 decades as a mode of respiratory support for children hospitalized with bronchiolitis. The growing use of HFNC despite a paucity of high-quality data regarding the therapy's efficacy has led to concerns about overutilization. We developed an electronic health record (EHR) embedded, quality improvement (QI) oriented clinical trial to determine whether standardized management of HFNC weaning guided by clinical decision support (CDS) results in a reduction in the duration of HFNC compared to usual care for children with bronchiolitis.
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- In a study of 41 patients with adrenocortical carcinoma (ACC), the expression of CXCR4 was analyzed using [Ga]Ga-PentixaFor PET/CT to evaluate its predictive value for patient outcomes compared to conventional clinical parameters.
- Results showed that higher tumor chemokine receptor binding (TRB) significantly correlated with shorter overall survival (OS), alongside the presence of CXCR4-positive peritoneal metastases.
- The findings suggest that elevated TRB is a strong independent predictor for poorer survival outcomes in advanced ACC, highlighting its potential utility in guiding treatment decisions.
Article Synopsis
- - Glucocorticoids are commonly used medications for inflammation and immune suppression, but over 1% of users may face a risk of adrenal insufficiency based on dosage, duration, and individual factors.
- - Managing adrenal insufficiency can be complex, especially when trying to taper off glucocorticoids, as withdrawal symptoms can mimic those of adrenal insufficiency.
- - A new joint guideline from the European Society of Endocrinology and Endocrine Society offers important recommendations for healthcare providers to effectively care for patients undergoing long-term glucocorticoid therapy.