Publications by authors named "S Hagihara"
Article Synopsis
- - Plants transport nutrients to chloroplasts during leaf development, but in times of senescence or sugar starvation, they use autophagy to degrade chloroplast proteins for nutrient recycling.
- - Researchers observed that in sugar-starved leaves, chloroplasts form budding structures that are released and incorporated into vacuoles as part of a process called autophagy, specifically involving Rubisco-containing bodies.
- - The study found that the budding process is linked to autophagosome formation, with isolation membranes of these structures interacting with chloroplasts, leading to fragmentation for degradation without requiring a known division protein for typical chloroplast replication.
Article Synopsis
- Nivolumab combined with chemotherapy has become the standard treatment for advanced HER2-negative gastric cancer, with a focus on understanding its long-term effects through clinical trials.
- In the ATTRACTON-4 trial, conducted across Japan, South Korea, and Taiwan, patients were assigned to either nivolumab or a placebo alongside common chemotherapy regimens, with the primary goals being progression-free survival and overall survival.
- After three years, the nivolumab group showed longer progression-free survival but similar overall survival compared to the placebo group, with a significant majority of patients who responded completely to treatment remaining alive, indicating its effective and safe use in this setting.
Article Synopsis
- Cells coordinate development and defense by sensing multiple signals, and a specific pathway for plant stomatal development is connected to the immunity pathway, although the details of this connection are unclear.
- Researchers discovered a small molecule, kC9, that promotes excessive stomatal differentiation by inhibiting a key receptor-kinase pathway, specifically targeting the MAP kinase MPK6.
- Interestingly, activating immune signaling with a bacterial peptide can counteract kC9's effects on stomatal development, revealing that the interplay between developmental and immune signals is managed by receptor availability and helps maintain signal specificity.
Arabinogalactan proteins (AGPs) are plant-specific glycoproteins involved in cellular mechanics and signal transduction. There has been major progress in understanding the structure, synthesis, and molecular functions of their carbohydrate chains; however, the mechanisms by which they function as signalling molecules remain unclear. Here, methyl-glucuronosyl arabinogalactan (AMOR; Me-GlcA-β(1,6)-Gal), a disaccharide structure at the end of AGP carbohydrate chains, was oligomerised chemical synthesis.
View Article and Find Full Text PDFRoot parasitic plants in the Orobanchaceae, such as Striga and Orobanche, cause significant damage to crop production. The germination step of these root parasitic plants is induced by host-root-derived strigolactones. After germination, the radicles elongate toward the host and invade the host root.
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