Publications by authors named "S Habnam Bakhshalizadeh"
Ceratonia siliqua L. pod Effects on Viability Gene Expression of Endometrial Mesenchymal Stromal/Stem Cells Isolated from Women with Endometriosis-Associated Infertility.
Int J Fertil Steril
October 2024
Background: This study aims to investigate the effects of carob (Ceratonia siliqua L.) pod extract (CPE) on the viability of human endometrial mesenchymal stromal/stem cells (EnMSCs) and its impact on mRNA and protein expressions of DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), histone deacetylase 1 (HDAC1), matrix metalloproteinase-2 (MMP2), and cyclooxygenase-2 (COX-2) in endometriotic patients.
Materials And Methods: In this experimental study, EnMSCs were derived from endometrium of patients with ovarian endometrioma (OMA-EnMSCs group) and deep infiltrative endometriosis (DIE) samples of 10 endometriosisassociated infertility (EAI) women (E-EnMSCs group) and compared to EnMSCs derived from the endometrium of an endometriosis-free, normal woman as the control group (C-EnMSCs).
Article Synopsis
- The study examined 10 potentially toxic elements in the muscle tissue of eight carnivorous fish species from the Caspian Sea, focusing on pollutants like cadmium (Cd) and lead (Pb).
- Although differences between fish species were minor, larger species showed higher mercury levels, raising concerns about human health, especially for children.
- The risk analysis indicated alarming cadmium and lead concentrations, while inorganic arsenic levels were deemed acceptable, highlighting the importance of ongoing monitoring to protect ecosystems and public health.
Premature ovarian insufficiency (POI) is characterized by the loss or complete absence of ovarian activity in women under the age of 40. Clinical presentation of POI varies with phenotypic severity ranging from premature loss of menses to complete gonadal dysgenesis. POI is genetically heterogeneous with >100 causative gene variants identified thus far.
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- Primary biliary cholangitis (PBC) is a liver and immune system condition, and a study investigated the effects of transplanting autologous bone marrow-derived mononuclear cells (BM-MNCs) in affected patients.
- Sixteen PBC patients underwent BM-MNC harvesting and transplantation between 2017 and 2022, with monitoring of liver function and immune cell changes over time using statistical analyses.
- The results showed significant improvements in liver function tests and notable changes in immune cell populations, suggesting that BM-MNC transplantation could be a promising therapeutic approach for managing PBC.
Background: In this phase I clinical trial, our primary objective was to develop an innovative therapeutic approach utilizing autologous bone marrow-derived mesenchymal stromal/stem cells (BM-MSCs) for the treatment of nonobstructive azoospermia (NOA). Additionally, we aimed to assess the feasibility and safety of this approach.
Materials And Methods: We recruited 80 participants in this non-randomized, open-label clinical trial, including patients undergoing NOA treatment using autologous BM-MSCs (n=40) and those receiving hormone therapy as a control group (n=40).