Elevated expression of REV7 correlates with poor prognosis in lung adenocarcinoma and its inactivation in carcinoma cells enhances chemosensitivity.

REV7 is a multifunctional protein involved in the DNA damage response, cell cycle regulation, gene expression, or primordial germ cell maintenance. REV7 expression in tumor cells is associated with clinical aggressive features and chemoresistance in several human malignancies, however, the clinicopathological significance of REV7 in lung adenocarcinoma (LUAD) has not been studied yet. In this study, we investigated the significance of REV7 expression in LUAD using clinical materials and cell lines.

Impact of femoral stem alignment on periprosthetic bone density in THA: a study of the Avenir Complete stem.

Introduction: Thigh pain, aseptic loosening, and failure after total hip arthroplasty has been reported. Therefore, this study examines the impact of femoral stem alignment on periprosthetic bone mineral density (BMD) in THA using the Avenir Complete cementless stem, focusing on the role of precise stem alignment in maintaining proximal femoral BMD.

Materials And Methods: Consecutive patients who received the Avenir Complete stem via mini anterolateral approach in the supine position between March 2019 and March 2022 were included.

is a potential therapeutic target for osteosarcoma: and evaluations using generated artificial osteosarcoma cancer stem cell‑like cells.

Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells.

[Association between health checkups, vaccination, and social isolation among people on public assistance: The case of Izumi Public Health and Welfare Center, Sendai City].

Objective　The healthcare management support program for public assistance recipients has been mandated at all welfare centers since 2021 because the importance of healthcare support for them has recently been recognized in Japan. However, the factors that hinder preventive healthcare service utilization have not been empirically investigated. This survey aimed to identify the relationship between health checkups, vaccination services, and social isolation among people on public assistance.

Delayed development of the inferior mesenteric vein in human fetuses.

Background: The superior mesenteric vein appears as a fusion between irregularly-shaped slits of the midgut mesentery tissue at 5-6 weeks. In contrast, there might be no report when and how the inferior mesenteric vein (IMV) develops. We aimed to find the human initial IMV.