Parametrization of the dying brain: A case report from ICU bed-side EEG monitoring.

Background: Cortical high-frequency activation immediately before death has been reported, raising questions about an enhanced conscious state at this critical time. Here, we analyzed an electroencephalogram (EEG) from a comatose patient during the dying process with a standard bedside monitor and spectral parameterization techniques.

Methods: We report neurophysiologic features of a dying patient without major cortical injury.

GalNT2-mediated O-glycosylation affects pancreas development and function in mice.

GALNT2, also known as polypeptide N-acetylgalactosaminyltransferase 2, is an enzyme that catalyzes the initial step of O-linked glycosylation, a crucial posttranslational modification that affects protein folding, stability, and function. Alterations in GALNT2 activity have been implicated in various diseases, such as cancer, metabolic disorders, and cardiovascular diseases, highlighting its importance in maintaining normal physiological functions. To investigate the impact of GalNT2 overexpression in vivo for the first time, we generated a conditional transgenic mouse line in which GalNT2 was expressed specifically in the pancreas.

Predicting Digital Accessibility Through a Self-Assessment Test of Process Traits.

We have developed an 11-question self-assessment test that predicts whether a team is likely to develop accessible digital solutions - or not - based on the characteristics of the development processes. Our results indicate the test can predict both successes and failures with regards to accessibility of digital solutions. As such, teams and product leaders now have an easy way to identify whether the team's knowledge, practices and mindset makes them likely to deliver accessible digital solutions.

Feasibility of trauma-focused cognitive behavioural therapy for patients with PTSD and psychosis.

Studies have shown a high prevalence of trauma and PTSD among patients with severe mental illness, but relatively few studies have examined the outcomes of PTSD treatment for this patient group. The aim of this case-series was to assess the feasibility of a Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) intervention for PTSD in people with psychosis. The study examined the possibilities and obstacles when treating this population within clinical settings.

A Rare Case of Magnesium Alkyl Mediated CO-to-Alkoxide Conversion.

Alcohols can be produced by nucleophilic addition at the C=O functional group of ketones or aldehydes. Such C-C bond formations generally proceed smoothly and selective. In contrast, nucleophilic addition at carbon monoxide is considerably more complex and unselective due to the instability of polar metal acyl intermediates.