Publications by authors named "S HARASHIMA"
Article Synopsis
- Research lacks a standardized multi-day antiemetic regimen for chemotherapy, making it difficult to assess efficacy and safety.
- A comprehensive search revealed no direct comparisons between multi-day and single-day antiemetic regimens, with variations in study quality and treatment protocols hindering robust analysis.
- Preliminary findings indicate that three-drug combination therapies, particularly using aprepitant, may outperform two-drug regimens; further research is needed to better define antiemetic approaches for multi-day chemotherapy.
Article Synopsis
- The study examines how the social environment affects frailty in older adults with diabetes, with a focus on differences between urban and rural living conditions.
- Researchers analyzed data from 417 participants, finding that frailty was notably higher among those in rural areas (29.7% robust) compared to urban areas (43.9% robust), along with other negative health indicators.
- The findings suggest that older adults in rural areas face increased frailty risks due to lower performance in instrumental and social daily activities, highlighting the need for targeted intervention programs to improve social connections and care access.
Article Synopsis
- The study focused on the impact of diabetes medications on older adults (ages 60-80) with type 2 diabetes, particularly looking at their frailty and complications related to diabetes.
- A total of 417 participants were assessed using various health metrics and tests, revealing that many were either frail or pre-frail, with specific drug types linked to different health outcomes.
- Results showed that certain medications correlated with lower or higher risks of complications and frailty, emphasizing the need for tailored treatment in older diabetic patients.
Article Synopsis
- The study aimed to explore changes in the diagnosis of gestational diabetes mellitus (GDM) in Japan during the COVID-19 pandemic, focusing on the use of simplified diagnostic criteria from the Japanese Society of Diabetes and Pregnancy (JSDP).
- Researchers surveyed 2159 obstetric facilities to gather information on their awareness and implementation of GDM diagnostic strategies during the pandemic.
- Findings showed that most facilities (90%) maintained their existing diagnostic processes, but some switched to JSDP criteria, discontinuing the 75-g oral glucose tolerance tests at various points in pregnancy.
Polyploid (2n, 3n, and 4n) genomes are known to be unstable in Saccharomyces cerevisiae. Here, we attempted construction of super-polypoid strains (defined as having higher ploidy than tetraploidy) up to 32n by using the matα2-PBT method that we newly developed and investigated their genomic stability. It is known that cell size increases as ploidy increases up to tetraploid.
View Article and Find Full Text PDF